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My first wall hit me in second-year university. It seemed as though every course was a “weeder” course. Organic chemistry, biochemistry, calculus—all these classes were utter beasts.
In the early 2000s, I worked with a company trying to develop a novel way to treat antibiotic-resistant infections using viruses that attacked the harmful bacteria. I learned that scientists had been struggling to make such a treatment viable since the 1920s. It looks like we've begun figuring out how to crack that nut! This is good news in our fight against antibiotic resistance.
That is, someone who has never seen a single movie in the MCU will experience Avengers: Endgame differently than a Marvel freak/nerd/expert (like me) who has seen all of them.